Adderall Vs. Vyvanse to treat ADHD What is the difference?

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It’s no secret that ADHD is not free of difficulties. Attention-deficit/hyperactivity disorder can look like issues with focus and prioritizing tasks or difficulties with impulse control.

ADHD medications can ease some of the issues related to ADHD. Although it’s by no means a cure-all however, a lot of people utilize it in conjunction with other methods to build an effective multi-modal approach to ADHD treatment. With all the options available to treat ADHD, it’s difficult when you begin your journey.

This article discusses the differences between two commonly used ADHD medications: Adderall and Vyvanse (aka Elvanse in Europe).

Too long; didn’t read

Adderall as well as Vyvanse are psychostimulants that are derived from amphetamine.

Both increase the level of chemical substances in the brain. These aid in the reduction of ADHD symptoms.

Adderall is a mixture of dextroamphetamine and amphetamine. Vyvanse is a combination of dextroamp and lisdexamfetamine.

Vyvanse is a prescription medication which means it’s an inactive drug that your body must transform into an active substance. (This is the reason Vyvanse is slower to begin and has a longer time-frame over Adderall.)

Adderall is available as instant release (IR) and extended-release (XR;ER) formulations, whereas Vyvanse is found in extended-release formulations (due because it’s an antidrug.)

The adverse reactions to the two drugs are comparable to those experienced by other medications.

The two Adderall and Vyvanse have proven to be effective for sufferers of ADHD. The most effective choice is different for people.

The main similarities between Adderall and Vyvanse

The most significant difference between these two ADHD medication is that they are exactly match in:

(Psycho)stimulants

Amphetamine-based

Substances in Schedule II (they are extremely high risk of dependence or abuse)

They’re stimulants. Both buy-vyvanse-online increase the neurotransmitters that are in the brain which enhance focus, calm anxious reactions, and lower the chance of impulse control. The primary neurotransmitters affected by stimulants include the dopamine receptor and the norepinephrine (aka noradrenaline) and are essential for brain function.1

Are there any important differences in Adderall as compared to Vyvanse?

Many believe that Adderall and Vyvanse are alike, however, while they have some commonalities but they do have major differences.

Different active ingredients

Active ingredients in Adderall consist of the dextroamphetamine (D-amphetamine) as well as amphetamine that increases norepinephrine and dopamine while reducing dopamine as well as norepinephrine absorption.

It is an antidrug which needs to be first transformed by the liver and it is then converted into dextroamphetamine prior to when the body is able to utilize it. After that, Vyvanse results in an increase in levels of norepinephrine and dopamine in the prefrontal cortex.2,3

How they’re processed

The main difference between Adderall as well as Vyvanse is the fact that both are metabolically processed.

The protodrug Vyvanse comes from meaning that the substance is an inactive drug that needs to go through a metabolic process in the body, which converts it chemically into a substance which is dynamic. This is why Vyvanse is slower to start working and isn’t available with a rapid “kickstart.”

Adderall does not count as an official prescription drug, so it will begin working more quickly, but it only last for several hours. Some may prefer the quick beginning, as it can help them become more aware of the exact moment the medication “kicks in.” Some users might are unable to use their bodies, and that’s the reason why they’d most likely select Vyvanse.

Time of release: immediately and extended

Adderall is available as immediately release (IR) and extended release (XR as well as Extended Release) formulations. Vyvanse is by design always an extended-release formula due to the fact that it’s a prescription drug.

This instant launch version Adderall is a drug that acts quickly but it’s not as effective. This IR Version of Adderall will last between 3 to 4 hours, as per the FDA. Because that Adderall’s IR (immediate publication) version is only for short time and a lot of people are taking multiple doses daily.

The extended-release variant offered by Adderall (Adderall XR) can last from between 8 and 12 hours which means that you typically only need one dose per day.

Vyvanse can take as long as an hour to kick in, but it could last between 12 and 14 hours. Typically, it is just one dose daily.

Dosage differences

I For reference, the abbreviation mg is a term used to indicate milligrams as a measurement.

Adderall doses

Release immediately

5 mg

7.5 mg

10 mg

12.5 mg

15 mg

20 mg

30 mg

The most popular dosage to begin with is to take Adderall 5 mg each day, whether every day or two times. The doctor who prescribes the medication can aid patients in determining the proper dosage.

Extended release

5 mg

10 mg

15 mg

20 mg

25 mg

30 mg

The recommended dosage to take Adderall the XR ranges between 10-20 mg per day with a maximum of 40 mg per day.

Vyvanse doses

Vyvanse is available as a capsule or chewable form. Both Vyvanse versions are available in the following doses:

10 mg

20 mg

30 mg

40 mg

50 mg

60 mg

70mg (only capsules)

The dosage for adults is 30 mg twice a daily. The dosage can be increased by 10-20 mg per week as needed, but not over 70 mg.

What are the adverse effects of Adderall and Vyvanse?

Adderall and Vyvanse both have similar adverse reactions. However, since Vyvanse is a prodrug, the effects of Vyvanse might not be as serious as the effects of Adderall.4

However, both drugs could result in any of the following:

Common side effects:

Dizziness

Dry mouth

Headaches

Loss of appetite

Changes in mood

Nausea

Tics, or body-focused repetitive behavior (BFRBs)

Trouble sleeping

Rare adverse reactions

Diarrhea

Fever

The body’s odor increases and buying vyvanse-online becomes more intense.

Muscle weakness

Extreme anxiety

Severe weight loss

Which is the best medication for ADHD?

Since different bodies have distinct constitutions and differing ways of expressing themselves, it’s difficult to determine which of Adderall as well as Vyvanse is the better option for you. Some people may be amazed by Adderall and the other is convinced that Adderall causes problems for them. Vyvanse doesn’t, but the reverse is also true.

Both are effective in treating ADHD The final decision is the decision is made dependent on the conversation you have with your doctor regarding the possible advantages and risks of each.

Look into pharmacogenetics testing

Testing for Pharmacogenetics is one kind of genetic test that can analyze your genetic profile to find out how you might react to certain drugs. DNA tests can identify genetic differences that affect the way your body’s metabolism and processing substances. Once the results are in at your physician’s office, they’ll be able to help you in selecting the medication that is most likely to be effective and be safe for your body.

Learn more about the pharmacogenetics of it here.

Sources:

1 Neuroscience and Biobehavioral Reviews | The Pharmacology of Amphetamine and Methylphenidate: Relevance to the Neurobiology of Attention-Deficit/Hyperactivity Disorder and Other Psychiatric Comorbidities

2 CNS Spectrums | Lisdexamfetamine Dimesylate: A Prodrug Stimulant for the Treatment of ADHD in Children and Adults

  1. Biomolecules, and Therapeutics Possibility to Lisdexamfetamine Dependence Both in the vivo as well as in vitro aspects
  2. The Future Medicinal Chemistry | Cytochrome P450-activated drugs

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